期刊
MOLECULAR CELL
卷 27, 期 3, 页码 380-392出版社
CELL PRESS
DOI: 10.1016/j.molcel.2007.05.041
关键词
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资金
- NCI NIH HHS [P50 CA090381, P50 CA 69568, P50 CA 90381, P50 CA069568] Funding Source: Medline
- NHGRI NIH HHS [R01 HG004069-01, R01 HG004069-02, R01 HG004069] Funding Source: Medline
Androgen receptor (AR) is a ligand -dependent transcription factor that plays a key role in prostate cancer. Little is known about the nature of AR cis-regulatory sites in the human genome. We have mapped the AR binding regions on two chromosomes in human prostate cancer cells by combining chromatin immunoprecipitation (ChIP) with tiled oligonucleotide microarrays. We find that the majority of AR binding regions contain noncanonical AR-responsive elements (AREs). Importantly, we identify a noncanonical ARE as a cis-regulatory target of AR action in TMPRSS2, a gene fused to ETS transcription factors in the majority of prostate cancers. In addition, through the presence of enriched DNA-binding motifs, we find other transcription factors including GATA2 and Octl that cooperate in mediating the androgen response. These collaborating factors, together with AR, form a regulatory hierarchy that governs androgendependent gene expression and prostate cancer growth and offer potential new opportunities for therapeutic intervention.
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