期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 72, 期 16, 页码 5968-5972出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo070411z
关键词
-
资金
- NCI NIH HHS [5R44 CA 096020-03] Funding Source: Medline
We describe the development of methodology which allows for the introduction of a second disulfide bond into a molecular framework with a pre-existing disulfide linker system. Compounds which contain an S-9-fluorenylmethyl-protected thiol and an additional disulfide linkage are deprotected in situ and trapped with an activated thiophile. This methodology allowed for the synthesis of the first molecule possessing two different biologically active agents covalently attached to a folate receptor targeting ligand unit via two disulfide-based release systems.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据