期刊
SCIENCE
卷 317, 期 5838, 页码 660-663出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1139952
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资金
- NCRR NIH HHS [P41 RR11823-10] Funding Source: Medline
- NIDDK NIH HHS [DK070696, DK067598, DK074798] Funding Source: Medline
DAF-2, an insulin receptor-like protein, regulates metabolism, development, and aging in Caenorhabditis elegans. In a quantitative proteomic study, we identified 86 proteins that were more or less abundant in long-lived daf-2 mutant worms than in wild-type worms. Genetic studies on a subset of these proteins indicated that they act in one or more processes regulated by DAF-2, including entry into the dauer developmental stage and aging. In particular, we discovered a compensatory mechanism activated in response to reduced DAF-2 signaling, which involves the protein phosphatase calcineurin.
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