期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 204, 期 8, 页码 1911-1922出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20070285
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资金
- NCI NIH HHS [R24 CA 92782, R24 CA092782] Funding Source: Medline
- NIAID NIH HHS [P01 AI054904, P01 AI54904] Funding Source: Medline
Unmethylated CpG-oligodeoxynucleotides (ODNs) are generally thought of as potent adjuvants with considerable therapeutic potential to enhance immune responses against microbes and tumors. Surprisingly, certain so-called stimulatory CpG-ODNs strongly inhibited the effector phase of inflammatory arthritis in the K/BxN serum transfer system, either preventively or therapeutically. Also unexpected was that the inhibitory influence did not depend on the adaptive immune system cells mobilized in an immunostimulatory context. Instead, they relied on cells of the innate immune system, specifically on cross talk between CD8 alpha(+) dendritic cells and natural killer cells, resulting in suppression of neutrophil recruitment to the joint, orchestrated through interleukin-12 and interferon-gamma. These findings highlight potential applications of CpG-ODNs and downstream molecules as antiinflarnmatory agents.
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