期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 204, 期 8, 页码 1737-1739出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20071251
关键词
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Oral tolerance has been argued to depend on special presentation of antigen in the gut. New studies support this idea by showing that the catalysis of vitamin A into retinoic acid (RA) in gut-associated dendritic cells (DCs) enhances the transforming growth factor (TGF)-beta-dependent conversion of naive T cells into regulatory T (T reg) cells and also directs T reg cell homing to the gut. These results reveal new tolerance mechanisms that will aid the use of T reg cells in the clinic.
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