期刊
TETRAHEDRON
卷 63, 期 32, 页码 7647-7653出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2007.05.044
关键词
tripeptides; Passerini reaction; enzymatic hydrolysis; non-coded amino acids; N-methylated peptides
A new, efficient method for the multicomponent synthesis of tripeptide mimetics is presented. Simple, chemoenzymatic transformations of Passerini reaction products enable the introduction of varied amino acid moieties into the tripeptide scaffold, with control of the stereochemistry. Additionally, this method allows the convenient introduction of a methyl group to the amide nitrogen, leading to derivatives of N-methylated amino acids-compounds of interest for medicinal chemistry. (C) 2007 Elsevier Ltd. All rights reserved.
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