期刊
MACROMOLECULAR BIOSCIENCE
卷 7, 期 8, 页码 1065-1074出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200700049
关键词
Alzheimer's disease; dendrimers; EPR; prions
Spin-probe and spin-label techniques were used to study the interactions of the A beta 1-28 peptide involved in Alzheimer disease and the PrP 106-126 peptide suspected to be preferentially involved in spongiform encephalopathies with three different types of dendrimers. A computer-aided EPR analysis of a positively charged and a neutral spin probe was performed by comparing the pure dendrimer and peptide systems with the dendrimer-peptide ones. Also spin-labeled PAMAM dendrimers were used to test the interactions. The results show the interactions between dendrimer and peptide monomer to be stronger for A beta 1-28 than for PrP 106-126. PAMAM dendrimers perturb the aggregation of the peptides more than PPI dendrimers do.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据