期刊
ANALYTICA CHIMICA ACTA
卷 797, 期 -, 页码 1-12出版社
ELSEVIER
DOI: 10.1016/j.aca.2013.07.035
关键词
DNA biosensors; Immunosensors; Electrochemistry; Signal amplification; Nanoparticles
资金
- Australian Research Council
- China Scholarship Council
Nanoparticles with desirable properties not exhibited by the bulk material can be readily synthesized because of rapid technological developments in the fields of materials science and nanotechnology. In particular their highly attractive electrochemical properties and electrocatalytic activity have facilitated achievement of the high level of signal amplification needed for the development of ultrasensitive electrochemical affinity biosensors for the detection of proteins and DNA. This review article explains the basic principles of nanoparticle based electrochemical biosensors, highlights the recent advances in the development of nanoparticle based signal amplification strategies, and provides a critical assessment of the likely drawbacks associated with each strategy. Finally, future perspectives for achieving advanced signal simplification in nanoparticles based biosensors are considered. (c) 2013 Elsevier B.V. All rights reserved.
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