期刊
CANCER LETTERS
卷 253, 期 1, 页码 43-52出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2007.01.004
关键词
HBx; RNAi; cisplatin; chemosensitivity; hepatocellular carcinoma
类别
The X protein of hepatitis B virus (HBx) is often expressed in human hepatocellular carcinoma (HCC) but its role on tumor growth is not fully clarified. In this study, RNA interference was employed to knockdown HBx expression in Hep3B HCC cells, which naturally express carboxyl-end truncated form of HBx frequently found in HCC tissues. Specific knockdown of HBx strongly inhibited cell growth and tumorigenicity in xenograft model. HBx repression induced apoptosis in Hep3B cells and significantly increased cell sensitivity to cisplatin-induced apoptosis. These results suggest that RNA interference-mediated HBx suppression exerts potent anti-proliferative and chemosensitizing effects in human HCC. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
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