期刊
TETRAHEDRON
卷 63, 期 33, 页码 7892-7898出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2007.05.077
关键词
organocatalysis; asymmetric aldol reaction; dipeptide; in the presence of water
The L-proline-based dipeptide has been discovered and developed as an efficient catalyst for the direct asymmetric aldol reactions of unmodified ketones with various aldehydes including aromatic, aliphatic, heteroaromatic, and unsaturated aldehydes in the presence of water at 0 degrees C. The resulted methodology and optimal conditions led to the corresponding aldol products with high yields (up to 94%) and good enantioselectivities (up to 97% ee). (C) 2007 Elsevier Ltd. All rights reserved.
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