期刊
JOURNAL OF INFECTIOUS DISEASES
卷 196, 期 4, 页码 505-509出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/519693
关键词
-
资金
- NIAID NIH HHS [AI030731, P01 AI030731, AI50132, AI071113, AI31448] Funding Source: Medline
Clinical and virologic manifestations of genital herpes simplex virus type 2 (HSV-2) infection vary widely. We examined frequencies of single-nucleotide polymorphisms (SNPs) in Toll-like receptors (TLRs) 2, 3, 4, and 9 in a prospective cohort of 128 HSV-2-infected persons whose viral shedding and lesion frequency was measured by daily sampling from genital secretions. Two TLR2 haplotypes (2 and 4) were associated with increased lesional (P = .008 and P = .03) and shedding (P = .02 and P = .001) rates. An SNP in haplotype 2 (- 15607A/G) was also associated with shedding (P = .01) and lesional (P = .008) rates. Polymorphisms in TLR2 may be in part responsible for differences in the severity of HSV-2 infection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据