期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 16, 页码 4641-4645出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.05.075
关键词
alpha-helix mimetic; pyridzaine; Bak/Bcl-X-L; protein-protein interaction; Diels-Alder
资金
- NCI NIH HHS [CA 113318, U19 CA113318] Funding Source: Medline
- NIGMS NIH HHS [R01 GM027932-28, R01 GM027932] Funding Source: Medline
The design and synthesis of alpha-helix peptidomimetics using inverse electron demand Diels-Alder reactions is described. The potency of the resulting pyridazine-based library to disrupt the Bak/Bcl-X-L interaction was tested using an in vitro fluorescence polarization assay. (c) 2007 Elsevier Ltd. All rights reserved.
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