期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 16, 页码 4495-4499出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.06.005
关键词
ageladine A; matrix metalloproteinase-12
Ageladine A (1) and its analogs 2-10 were expeditiously synthesized by featuring the biosynthetic route proposed for I (for 1-10) and by employing 2-(N-t-butoxycarbonylamino)imidazol-4-carbaldehyde as the starting material (for 1-8). From MMP-12 inhibitory activity assay, it appeared evident that the two bromine atoms and the three NH groups (1-NH, 14-NH, and 15-NH2) were indispensable for 1 to exhibit excellent activity. (c) 2007 Elsevier Ltd. All rights reserved.
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