期刊
JOURNAL OF IMMUNOLOGY
卷 179, 期 4, 页码 2493-2500出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.179.4.2493
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- NCI NIH HHS [CA 33399, CA34233] Funding Source: Medline
- NIAID NIH HHS [T32 AI007290] Funding Source: Medline
Established widely metastatic tumor was cured in a transplanted mouse B cell lymphoma model, by the combination of chemotherapy plus intratumoral injection of oligodeoxynucleotides containing unmethylated C-G motifs (CpG). This therapeutic effect required that the CpG be injected directly into the tumor and was dependent on CD8 T cells. Although the efficacy of CpG oligodeoxynucleotides has been thought to depend on the expression of TLR9, we unexpectedly found that tumor rejection did not require host expression of TLR9. By using a TLR9-deficient tumor and a TLR9KO host, we demonstrate that TLR9 expression either by the host or the tumor is required. These results indicate that activation of Ag presentation by cells within the tumor via TLR9 stimulation can be an effective form of immunotherapy. This study forms the basis of an ongoing clinical trial in patients with lymphoma.
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