期刊
AMERICAN JOURNAL OF EPIDEMIOLOGY
卷 166, 期 4, 页码 393-402出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwm096
关键词
cardiovascular diseases; diabetes mellitus; type 1; glycosylation; hyperglycemia; mortality; Wisconsin
资金
- NEI NIH HHS [EY03083] Funding Source: Medline
Hyperglycemia is implicated in the development and progression of microvascular complications in type 1 diabetes. In contrast, the association between hyperglycemia and macrovascular complications or mortality in type 1 diabetes is not clear. The authors studied a population-based cohort of 879 individuals with type 1 diabetes from Wisconsin, free of cardiovascular disease and end-stage renal disease at the baseline examination (1980-1982). The main outcome of interest was all-cause (n = 201) and cardiovascular (n = 132) mortality as of December 31, 2001. Elevated glycosylated hemoglobin levels were associated with all-cause and cardiovascular mortality, independent of duration of diabetes, smoking, hypertension, and proteinuria. The multivariable relative risks comparing the highest quartile of glycosylated hemoglobin (>= 12.1%) with the lowest quartile (<= 9.4%) were 2.42 (95% confidence interval: 1.54, 3.82; p-trend = 0.0006) for all-cause mortality and 3.28 (95% confidence interval: 1.77, 6.08; p-trend < 0.0001) for cardiovascular mortality. This association was present among both sexes and persisted in subgroup analyses by categories of diabetes duration, smoking, body mass index, proteinuria, and retinopathy. These data suggest that hyperglycemia is associated with all-cause and cardiovascular mortality among individuals with type 1 diabetes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据