期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 129, 期 32, 页码 9856-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja0737927
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资金
- NIGMS NIH HHS [GM 077173] Funding Source: Medline
A sensor array comprising six functionalized poly(p-phenyleneethynylene) polymers was constructed and used to detect and identify protein analytes. The presence of proteins alters the fluorescence properties of the polymers, generating a distinct fluorescence response pattern for a given protein. Linear discriminant analyses accurately differentiate the patterns of 17 proteins at nano- to micromolar concentrations. An identification accuracy of 97% was obtained on the basis of the tests with 68 unknown protein samples from the training set.
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