期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 16, 页码 4415-4418出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.06.030
关键词
mGluR5; antagonist; MPEP
Rational replacement of the alkyne linker of mGluR5 antagonist MPEP gave 7-arylquinolines. SAR optimization gave an orally active compound with high affinity for the MPEP binding site. (c) 2007 Elsevier Ltd. All rights reserved.
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