期刊
ANALYTICA CHIMICA ACTA
卷 777, 期 -, 页码 1-16出版社
ELSEVIER
DOI: 10.1016/j.aca.2013.01.025
关键词
Optical biosensors; Surface biofunctionalization; Label free; Integrated biosensors
资金
- Spanish Ministry of Science and Innovation [CTQ2010-15943/BQU]
- Regional Valencian Government [GVA/PROMETEO 2010/08]
Increasing interest has been paid to label-free biosensors in recent years. Among them, refractive index (RI) optical biosensors enable high density and the chip-scale integration of optical components. This makes them more appealing to help develop lab-on-a-chip devices. Today, many RI integrated optical (IO) devices are made using silicon-based materials. A key issue in their development is the biofunctionalization of sensing surfaces because they provide a specific, sensitive response to the analyte of interest. This review critically discusses the biofunctionalization procedures, assay formats and characterization techniques employed in setting up IO biosensors. In addition, it provides the most relevant results obtained from using these devices for real sample biosensing. Finally, an overview of the most promising future developments in the fields of chemical surface modification and capture agent attachment for IO biosensors follows. (C) 2013 Elsevier B.V. All rights reserved.
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