期刊
ANALYTICA CHIMICA ACTA
卷 787, 期 -, 页码 24-35出版社
ELSEVIER
DOI: 10.1016/j.aca.2013.04.064
关键词
Droplet-based microfluidics; Analytical detection technique; Imaging; Molecular spectroscopy; Mass spectrometry; Capillary electrophoresis
资金
- National Natural Science Foundation of China [20825517, 21027008, 21105089]
- Ministry of Science and Technology of China [2009BAK59B01]
- China Postdoctoral Science Foundation [20110491775]
In the last decade, droplet-based microfluidics has undergone rapid progress in the fields of single-cell analysis, digital PCR, protein crystallization and high throughput screening. It has been proved to be a promising platform for performing chemical and biological experiments with ultra-small volumes (picoliter to nanoliter) and ultra-high throughput. The ability to analyze the content in droplet qualitatively and quantitatively is playing an increasing role in the development and application of droplet-based microfluidic systems. In this review, we summarized the analytical detection techniques used in droplet systems and discussed the advantage and disadvantage of each technique through its application. The analytical techniques mentioned in this paper include bright-field microscopy, fluorescence microscopy, laser induced fluorescence, Raman spectroscopy, electrochemistry, capillary electrophoresis, mass spectrometry, nuclear magnetic resonance spectroscopy, absorption detection, chemiluminescence, and sample pretreatment techniques. The importance of analytical detection techniques in enabling new applications is highlighted. We also discuss the future development direction of analytical detection techniques for droplet-based microfluidic systems. (C) 2013 Elsevier B.V. All rights reserved.
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