期刊
PHYSIOLOGY & BEHAVIOR
卷 91, 期 5, 页码 632-643出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2007.03.027
关键词
calcium appetite; ionized calcium; bone mineral density; calcium lactate; inbred strain; mouse phenome
资金
- NCRR NIH HHS [S10 RR026752, S10 RR025607] Funding Source: Medline
- NIDDK NIH HHS [R01 DK058797, DK058797, R01 DK094759, R01 DK046791-13, R01 DK046791, DK46791, R01 DK058797-08] Funding Source: Medline
We measured voluntary calcium intake, blood calcium, and bone mineral content of male and female mice from 40 inbred strains. Calcium intakes were assessed using 48-h two-bottle tests with a choice between water and one of the following: water, 7.5, 25, and 75 mM CaCl2, then 7.5, 25, and 75 mM calcium lactate (CaLa). Intakes were affected by strain, sex, anion, and concentration. In I I strains females consumed more calcium than did males and in the remaining 29 strains there were no sex differences. Nine strains drank more CaLa than CaCl2 whereas only one strain (JFI/Ms) drank more CaCl2 than CaLa. Some strains had consistently high calcium intakes and preferred all calcium solutions relative to water (e.g., PWK/PhJ, BTBR T+ tf/J, JFI/Ms). Others had consistently low calcium intakes and avoided all calcium solutions relative to water (e.g., KY,/H1J, C57BL/10J, CE/J, C58/J). After behavioral tests, blood was sampled and assayed for pH, ionized calcium concentration, and plasma total calcium concentration. Bone mineral density and content were assessed by DEXA. There were no significant correlations between any of these physiological measures and calcium intake. However, strains of mice that had the highest calcium intakes generally fell at the extremes of the physiological distributions. We conclude that the avidity for calcium is determined by different genetic architecture and thus different physiological mechanisms in different strains. (C) 2007 Elsevier Inc. All rights reserved.
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