期刊
TOXICOLOGY
卷 238, 期 1, 页码 23-33出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.tox.2007.05.019
关键词
neurotoxicity; electromagnetic fields; astrocyte; GFAP; rat; brain
Because of the increasing use of mobile phones, the possible risks of radio frequency electromagnetic fields adverse effects on the human brain has to be evaluated. In this work we measured GEAP expression, to evaluate glial evolution 2, 3, 6 and 10 days after a single GSM exposure (15 min, brain averaged SAR = 6W/kg, 900MHz signal) in the rat brain. A statistically significant increase of GEAP stained surface area was observed 2 days after exposure in the frontal cortex and the caudate putamen. A smaller statistically significant increase was noted 3 days after exposure in the same areas and in the cerebellum cortex. Our results confirm the Mausset-Bonnefont et al. study [Mausset-Bonnefont, A.L., Hirbec, H., Bonnefont, X., Privat, A., Vignon, J., de Seze, R., 2004. Acute exposure to GSM 900 MHz electromagnetic fields induces glial reactivity and biochemical modifications in the rat brain. Neurobiol. Dis. 17, 445-454], showing the existence of glial reactivity after a 15 min GSM acute exposure at a brain averaged SAR of 6 W/kg. We conclude to a temporary effect, probably due to a hypertrophy of glial cells, with a temporal and a spatial modulation of the effect. Whether this effect could be harmful remains to be studied. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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