期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 72, 期 17, 页码 6602-6605出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo0708341
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Deprotonation of pyrazine, pyridazine, pyrimidine, and quinoxaline using an in situ mixture of ZnCl2 center dot TMEDA (0.5 equiv) and LiTMP (1.5 equiv) was studied. Pyrazine and pyrimidine were deprotonated in THF at room temperature, a result evidenced by trapping with I-2. The competitive formation of dimer observed in net hexane was reduced by using cosolvents (TMEDA or THF). Starting from quinoxaline, the dimer formation took place in THF also, and mixtures of mono- and diiodides were obtained whatever the solvent and conditions used. A similar competitive formation of a diiodide was noted with pyridazine; the use of THF at reflux temperature nevertheless afforded the 3-iodo derivative in good yield.
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