期刊
ANALYTICA CHIMICA ACTA
卷 710, 期 -, 页码 118-124出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2011.10.035
关键词
Cobalt hexacyanoferrate; Multi-walled carbon nanotubes; Chemically modified electrode; Microfluidic chip; Hydrazine
资金
- National Natural Science Foundation of China [20727006, 21075139]
- Fundamental Research Funds for the Central Universities
- Guangdong Provincial Science and Technology Project [2008A030102009]
Nanomaterial-based electrochemical sensor has received significant interest. In this work, cobalt hexacyanoferrate modified multi-walled carbon nanotubes/graphite composite electrode was electrochemically prepared and exploited as an amperometric detector for microchip electrophoresis. The prepared sensor displayed rapid and sensitive response towards hydrazine and isoniazid oxidation, which was attributed to synergetic electrocatalytic effect of cobalt hexacyanoferrate and multi-walled carbon nanotubes. The sensitivity enhancement with nearly two orders of magnitude was gained, compared with the bare carbon paste electrode, with the detection limit of 0.91 mu M (S/N=3) for hydrazine. Acceptable repeatability of the microanalysis system was verified by consecutive eleven injections of hydrazine without chip and electrode treatments, the RSDs for peak current and migration time were 3.4% and 2.1%, respectively. Meanwhile, well-shaped electrophoretic peaks were observed, mainly due to fast electron transfer of electroactive species on the modified electrode. The developed microchip-electrochemistry setup was successfully applied to the determination of hydrazine and isoniazid in river water and pharmaceutical preparation, respectively. Several merits of the novel electrochemical sensor coupled with microfluidic platform, such as comparative stability, easy fabrication and high sensitivity, hold great potential for hydrazine compounds assay in the lab-on-a-chip system. (C) 2011 Elsevier B.V. All rights reserved.
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