期刊
ANALYTICA CHIMICA ACTA
卷 683, 期 2, 页码 227-233出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2010.10.034
关键词
Bisphenols; Soft drink beverages; Fused-Core (TM) column; On-line solid phase extraction (SPE)
资金
- Spanish Ministerio de Ciencia y Tecnologia [CTQ2009-09253]
In this study, an automated on-line solid-phase extraction coupled to fast liquid chromatography-tandem mass spectrometry (on-line SPE fast LC-MS/MS) method was developed for the simultaneous analysis of bisphenol A (BPA), bisphenol F (BPF), bisphenol E (BPE), bisphenol B (BPB) and bisphenol S (BPS) in canned soft drinks without any previous sample treatment. A C18 (12 mu m particle size) loading column was used for the SPE on-line preconcentration before the liquid chromatography baseline separation of bisphenol compounds using a C18 Fused-Core (TM) (50 mm x 2.1 mm i.d.) column, which took less than 3 min. Gradient elution and heated electrospray were used to reduce matrix effect and improve ionization efficiency. To select the most intense and selective transitions, fragmentation studies were performed by multiple-stage mass spectrometry in an ion trap mass analyzer and tandem mass spectrometry in a triple quadrupole instrument, this latter instrument being used for quantitation in SRM mode. Quality parameters of the method were established and we obtained a simple, fast, reproducible (RSD values lower than 10%) and accurate (precision higher than 93%) method for the analysis of bisphenols in canned soft drinks at the ng L-1 level using matrix-matched calibration. (C) 2010 Elsevier B.V. All rights reserved.
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