期刊
ANALYTICA CHIMICA ACTA
卷 689, 期 2, 页码 219-225出版社
ELSEVIER
DOI: 10.1016/j.aca.2011.01.045
关键词
Orthogonal array design; Hollow fiber protected liquid-phase microextraction; High-performance liquid chromatography; Salicylates; Environmental analysis
资金
- Nature Science Fund of Hubei Province [2010CDB03205]
- National Nature Science Foundation of China [21075091]
- Huazhong University of Science and Technology [0124514009]
- Tongji Medical School [01-25-514021]
- Important National Science & Technology Specific Projects [2009ZX09301-014]
In the present study, a three phase-based hollow fiber protected liquid-phase microextraction (HF-LPME) method combined with high-performance liquid chromatography (HPLC) for the determination of salicylates in environmental waters was developed. The HF-LPME procedure was optimized by an L-16(4(5)) orthogonal array experimental design (OAD) with five factors at four levels. Under the optimal extraction condition (pHs of donor and receiving phases of 3.0 and 6.2, respectively, extraction time of 45 min, stirring speed of 1000 rpm, and salt addition of 20% (w/v)), salicylates could be determined in a linear range from 0.025 to 1.0 mu g mL(-1) with a good correlation (r(2) > 0.9930). The limits of detection (LODs) ranged between 0.6 ng mL(-1) and 1.2 ng mL(-1) for the target analytes. The relative standard deviations (RSDs) of intra-day and inter-day were in the range of 0.64-14.58% and 0.16-15.45%, respectively. This procedure afforded a convenient, sensitive, accurate and cost-saving operation with high extraction efficiency for the model analytes. The method was applied satisfactorily to the determination of salicylates in two environmental waters. (C) 2011 Elsevier B.V. All rights reserved.
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