期刊
FEBS LETTERS
卷 581, 期 21, 页码 3961-3966出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2007.07.028
关键词
mesenchymal stem cell; cardiac fibroblast; cell proliferation; collagen; paracrine effect; collagenase activity
Mesenchymal stem cells (MSC) transplantation has been shown to decrease fibrosis in the heart; however, whether MSC directly influence the function of cardiac fibroblasts (CFB) remains unknown. MSC-conditioned medium significantly attenuated proliferation of CFB compared with CFB-conditioned medium. MSC-conditioned medium upregulated antiproliferation-related genes such as elastin, myocardin and DNA-damage inducible transcript 3, whereas CFB-conditioned medium upregulated proliferation-related genes such as alpha-2-macrogrobulin and v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog. MSC-conditioned medium significantly downregulated type I and III collagen expression, and significantly suppressed type III collagen promoter activity. MSC may exert paracrine anti-fibrotic effects at least in part through regulation of CFB proliferation and collagen synthesis. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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