期刊
BEHAVIOURAL BRAIN RESEARCH
卷 182, 期 1, 页码 140-144出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2007.05.003
关键词
delta-opioid receptor; naltrindole 5'-isothiocyanate; nucleus accumbens; cocaine
资金
- NIDA NIH HHS [R01 DA012498, R01DA12498, R01 DA012498-05] Funding Source: Medline
Whether the delta-opioid receptor (DOR) system can modulate behavioral effects of cocaine remains equivocal. We examined whether site- and subtype-selective blockade of DORs within the rat mesocorticolimbie system affects cocaine self-administration. The DOR antagonist naltrindole 5'-isothiocyanate (5'-NTII; 5 nmol) was microinjected into the nucleus accumbens (NAcc), ventral tegmental area (VTA), or arnygdala (AMYG) in rats self-administering 1.5 mg/kg cocaine under a progressive ratio (PR) schedule. Intra-NAcc 5'-NTII significantly decreased cocaine self-administration, while 5'-NTII administration into the VTA significantly increased cocaine-maintained responding. 5-NTII administration into the AMYG produced no effect. These data support a site-specific role of DORs in cocaine's behavioral effects. (c) 2007 Elsevier B. V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据