期刊
JOURNAL OF NEUROSCIENCE
卷 27, 期 34, 页码 9181-9191出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1588-07.2007
关键词
fMRI; optical imaging; primate; somatosensory cortex; digits; topography
资金
- NIBIB NIH HHS [EB000461, T32 EB001628, EB002326, R01 EB000461, R01 EB002326] Funding Source: Medline
- NIDCR NIH HHS [DE16606, R03 DE016606] Funding Source: Medline
- NINDS NIH HHS [R56 NS044375, NS044375, R01 NS044375] Funding Source: Medline
Although blood oxygenation level-dependent ( BOLD) functional magnetic resonance imaging ( fMRI) has been widely used to explore human brain function, questions remain regarding the ultimate spatial resolution of positive BOLD fMRI, and indeed the extent to which functional maps revealed by positive BOLD correlate spatially with maps obtained with other high-spatial-resolution mapping techniques commonly used in animals, such as optical imaging of intrinsic signal (OIS) and single-unit electrophysiology. Here, we demonstrate that the positive BOLD signal at 9.4T can reveal the fine topography of individual fingerpads in single-condition activation maps in nonhuman primates. These digit maps are similar to maps obtained from the same animal using intrinsic optical imaging. Furthermore, BOLD fMRI reliably resolved submillimeter spatial shifts in activation in area 3b previously identified with OIS ( Chen et al., 2003) as neural correlates of the funneling illusion. These data demonstrate that at high field, high-spatial-resolution topographic maps can be achieved using the positive BOLD signal, weakening previous notions regarding the spatial specificity of the positive BOLD signal.
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