Synthesis of (-)-lapatin B

The synthesis of (-)-lapatin B (1) has been achieved from L-tryptophan. The key reactions involve oxidative cyclization of N,N-diacetylglyantrypine (8) using PhI(OH)(OTs), and an indole-to-oxindole transformation in the penultimate step. (C) 2007 Elsevier Ltd. All rights reserved.