期刊
TETRAHEDRON LETTERS
卷 48, 期 35, 页码 6080-6083出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.06.150
关键词
indole; Atherton-Todd reaction; phosphonamidate; plague; yersiniabactin
We report the synthesis of an adenosyl-derived indolylphosphonamide analogue of salicyladenosylmonophosphate involved in the plague and tuberculosis siderophore biosyntbeses. The compound proved to be a potent inhibitor of the Yersinia pestis salicylate adenylation domain YbtE catalyzing the initial step of yersiniabactin biosynthesis. (c) 2007 Elsevier Ltd. All rights reserved.
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