期刊
CANCER LETTERS
卷 254, 期 1, 页码 30-41出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2007.01.015
关键词
amphiregulin; proliferation; liver injury; cirrhosis; hepatocarcinoma; carcinogenesis
类别
Amphiregulin (AR) is a member of the epidermal growth factor family and a ligand of the epidermal growth factor receptor (EGFR). As other ligands of the EGFR, AR is synthesized as a precursor that is shed from the plasma membrane by metalloproteases. Hyperactive autocrine loops involving AR production have been described in a variety of tumors, and this growth factor is thought to play a non-redundant role in cancer development. AR expression is not detected in the normal liver, however it is readily induced during acute liver injury and behaves as a potent pro-regenerative and survival factor. Increased AR expression is also detected in human chronic liver injury (liver cirrhosis), which is considered a pre-neoplastic condition. Recent evidences suggest that AR can play a unique role in liver tumorigenesis and in the maintenance of the neoplastic phenotype of hepatocarcinoma cells. In this review, we summarize some aspects of AR patho-biology and the rationale behind its definition as a novel target in hepatocarcinoma therapy. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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