期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 362, 期 1484, 页码 1293-1312出版社
ROYAL SOC
DOI: 10.1098/rstb.2007.2134
关键词
elastic fibres; blood vessels; tissue engineering; elastin; fibrillin; fibulin
类别
资金
- MRC [G0200246] Funding Source: UKRI
- Medical Research Council [G0200246] Funding Source: Medline
- Medical Research Council [G0200246] Funding Source: researchfish
For the treatment of vascular disease, the major cause of death in Western society, there is an urgent need for tissue-engineered, biocompatible, small calibre artery substitutes that restore biological function. Vascular tissue engineering of such grafts involves the development of compliant synthetic or biomaterial scaffolds that incorporate vascular cells and extracellular matrix. Elastic fibres are major structural elements of arterial walls that can enhance vascular graft design and patency. In blood vessels, they endow vessels with the critical property of elastic recoil. They also influence vascular cell behaviour through direct interactions and by regulating growth factor activation. This review addresses physiological elastic fibre assembly and contributions to vessel structure and function, and how elastic fibre biology is now being exploited in small diameter vascular graft design.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据