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N-heterocyclic carbene catalyzed ring expansion of 4-formyl-β-lactams:: Synthesis of succinimide derivatives

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ORGANIC LETTERS
卷 9, 期 18, 页码 3519-3521

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AMER CHEMICAL SOC
DOI: 10.1021/ol0713537

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N-Heterocyclic carbene (NHC) has been employed as an efficient catalyst for ring expansion of 4-formyl-beta-lactams, allowing the facile synthesis of succinimide derivatives. This organocatalytic process features readily availability of the catalyst, low catalyst loading, and mild reaction conditions.

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