期刊
ANALYTICA CHIMICA ACTA
卷 673, 期 2, 页码 179-184出版社
ELSEVIER
DOI: 10.1016/j.aca.2010.05.036
关键词
Gold nanorods; Localized surface plasmon resonance; DNA detection; Optical sensor
资金
- Beijing Municipal Education Commission [KM200810028010]
- Beijing Municipality [PHR20100718]
Sequence-specific DNA detection is important in various biomedical applications such as gene expression profiling, disease diagnosis and treatment, drug discovery and forensic analysis. Herein, the localized surface plasmon resonance properties of unmodified gold nanorods (GNRs) in 1 mM cetyltrimethylammonium bromide solution were used for sensing DNA sequences, with good simplicity and sensitivity. The intensity of typical plasmon resonance absorption bands of the GNRs decreased with increasing cDNA concentration. The detection of a 30-mer single-stranded oligonucleotide as a model reached a detection limit of about 0.1 pM. This study will be significant for as-prepared GNRs for future application in biological systems. (c) 2010 Elsevier B.V. All rights reserved.
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