期刊
SCIENCE
卷 317, 期 5842, 页码 1220-1224出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1140481
关键词
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资金
- NINDS NIH HHS [R01 NS064433, R01 NS064433-01] Funding Source: Medline
MicroRNAs ( miRNAs) are evolutionarily conserved, 18- to 25- nucleotide, non-protein coding transcripts that posttranscriptionally regulate gene expression during development. miRNAs also occur in postmitotic cells, such as neurons in the mammalian central nervous system, but their function is less well characterized. We investigated the role of miRNAs in mammalian midbrain dopaminergic neurons ( DNs). We identified a miRNA, miR-133b, that is specifically expressed in midbrain DNs and is deficient in midbrain tissue from patients with Parkinson's disease. miR-133b regulates the maturation and function of midbrain DNs within a negative feedback circuit that includes the paired-like homeodomain transcription factor Pitx3. We propose a role for this feedback circuit in the fine-tuning of dopaminergic behaviors such as locomotion.
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