期刊
PHARMACOLOGICAL RESEARCH
卷 56, 期 3, 页码 193-201出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2007.06.003
关键词
berberine interleukin-1 beta; tumor necrosis factor-a; pulmonary inflammation; inhibitory kappa B-alpha
Pulmonary inflammation is a characteristic of many lung diseases. Increased levels of pro-inflammatory cytokines, such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha), have been correlated with lung inflammation. In this study, we demonstrated that various inflammatory agents, including lipopolysaccharide, 12-o-tetradecanoylphorbol-13-acetate, hydrogen peroxide, okadaic acid and ceramide, were able to induce IL-1 beta and TNF-alpha productions in human lung epithelial cells (A-549), fibroblasts (HFL1), and lymphoma cells (U-937). Berberine, the protoberberine alkaloid widely distributed in the plant kingdom, was capable of suppressing inflammatory agents-induced cytokine production in lung cells. Inhibition of cytokine production by berberine was dose-dependent and cell type-independent. Moreover, the suppression of berberine on the cytokine production resulted from the inhibition of inhibitory kappa B-alpha phosphorylation and degradation. In conclusion, our findings Suggested the potential role of berberine in the treatment of pulmonary inflammation. (c) 2007 Elsevier Ltd. All rights reserved.
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