期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 17, 页码 4929-4933出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.06.023
关键词
cathepsin; cathepsin S; enzyme inhibitors; trifluoroethylamine; nitrile; sulfone; antigen presentation
Highly potent, selective, and bioavailable inhibitors of human, mouse, or rat cathepsin S are described. The key structural features combine a sulfonyl moiety attached to a large group in P2 and a small substituent in P3. (C) 2007 Elsevier Ltd. All rights reserved.
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