期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 389, 期 2, 页码 433-440出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-007-1364-2
关键词
molecular imprinting; resolution; OMNiMIPs; crosslinkers; enantioselectivity; chromatography
New monomers were synthesized and evaluated for their molecular imprinting performance by a recently discovered methodology referred to as one monomer molecularly imprinted polymers (OMNiMIPs). The structural design of the new monomers was based on a lead compound methacrylamidoethyl methacrylate (1) used for the synthesis of OMNiMIP1, and introduced alkyl groups of various sizes at the alpha-amino position of the lead compound. Enantioselectivity, determined by liquid chromatography, was used to compare the performance of the imprinted polymers. Methyl substitution provided crosslinker 5 (2-methacrylamidopropyl methacrylate), which upon imprint polymerization afforded OMNiMIP5 with approximately the same enantioselectivity (alpha=3.8) as OMNiMP1 (alpha=3.7) made with the lead compound (1). The other two monomers (6 and 7) with larger alkyl substitutions (isopropyl and sec-butyl respectively) resulted in OMNiMIPs with low selectivity values (alpha=1.0 and 1.2 respectively). Last, a strong influence of diastereomeric complexes on OMNiMIP5 selectivity was determined, with L/L and D/D monomer/template pairs giving alpha values of 3.6-3.8, while L/D and D/L monomer/template pairs had alpha values of 2.3-2.4. There is no intrinsic enantioselectivity seen for the OMNiMIP5 control polymer made without template at all, giving an alpha value of 1.03.
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