期刊
TRENDS IN GENETICS
卷 23, 期 9, 页码 422-426出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2007.05.005
关键词
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The tryptophan biosynthetic operon has been widely used as a model system for studying transcription regulation. In Bacillus subtilis, the trp operon is primarily regulated by a tryptophan-activated RNA-binding protein, TRAP. Here we show that in many other Gram-positive species the trp operon is regulated differently, by tRNA(Trp) sensing by the RNA-based T-box mechanism, with T-boxes arranged in tandem. Our analyses reveal an apparent relationship between trp operon organization and the specific regulatory mechanism(s) used.
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