期刊
SLEEP MEDICINE
卷 8, 期 6, 页码 656-667出版社
ELSEVIER
DOI: 10.1016/j.sleep.2006.12.010
关键词
circadian rhythm; heart; metabolism; gene expression
资金
- NHLBI NIH HHS [R01 HL074259-03, R01 HL074259-02, R01 HL074259, R01 HL074259-04, HL-074259-01, R01 HL074259-05] Funding Source: Medline
Circadian clocks are intracellular molecular mechanisms designed to allow the cell, organ, and organism to prepare for an anticipated stimulus prior to its onset. In order for circadian clocks to maintain their selective advantage, they must be entrained to the environment. Light, sound, temperature, physical activity (including sleep/wake transitions), and food intake are among the strongest environmental factors influencing mammalian circadian clocks. Normal circadian rhythmicities in these environmental factors have become severely disrupted in our modern day society, concomitant with increased incidence of type 2 diabetes mellitus, obesity, and cardiovascular disease. Here, we review our current knowledge regarding the roles of peripheral circadian clocks, concentrating on those found within tissues directly involved in metabolic homeostasis and cardiovascular function. We propose that both interand intra-organ dyssynchronization, through alteration/impairment of peripheral circadian clocks, accelerates the development of cardiovascular disease risk factors associated with cardiometabolic syndrome. Published by Elsevier B.V.
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