期刊
AMERICAN JOURNAL OF HYPERTENSION
卷 20, 期 9, 页码 1007-1015出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjhyper.2007.03.017
关键词
vitamin D; macrophages; chronic inflammatory disease; arterial stiffening; atherosclerosis; hypertension
Low dietary intake of calcium stimulates the activation of vitamin D-3 precursors to calcitriol in the kidney. This circulating hormone raises blood and urinary calcium by increasing both gastrointestinal absorption of calcium and bone resorption. Renal activation of vitamin D-3 is under tight feedback control. Macrophages also activate vitamin D-3, but, unlike renal tubular cells, they lack feedback suppression of the activating 1 alpha-hydroxylase. In large-scale epidemiologic studies, blood pressure correlated positively with serum and urinary calcium but inversely with the dietary intake of calcium. Several population-based reports, including the Framingham Study, noticed an association of carotid plaques, arterial calcification, and increased arterial stiffness with lower bone-mineral content. Randomized clinical trials of calcium supplementation did not demonstrate a consistent effect on blood pressure. Macrophages in atherosclerotic lesions can locally activate vitamin D-3 to calcitriol, which might contribute to arterial stiffening and hypertension. Calcitriol acts as a vasoactive and pro-oxidative substance on vascular smooth muscle cells. In animal models, active vitamin D-3 promotes arterial stiffening and the pathogenesis of systolic hypertension and perpetuates a self-sustaining cycle leading to arterial damage and calcification. On the other hand, active vitamin D-3 inhibits renin activity, thereby decreasing blood pressure in short-term, randomized trials. This article assesses the potential role of active vitamin D-3 in causing cardiovascular complications via its effects on the structure of the arterial wall and the pathogenesis of hypertension. To set the stage and open up new perspectives, our article also summarizes the pathways leading to the renal and extrarenal activation and metabolism of vitamin D-3 and will propose some directions for further research in this complex field.
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