4.6 Article

Changes of skin collagen orientation associated with chronological aging as probed by polarized-FTIR micro-imaging

期刊

ANALYST
卷 139, 期 10, 页码 2482-2488

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3an00353a

关键词

-

资金

  1. Champagne-Ardenne Region
  2. INSERM PNR Imagerie
  3. CNRS PIR Longevite et Vieillissement

向作者/读者索取更多资源

During chronological skin aging, alterations in dermal structural proteins cause morphological modifications. Modifications are probably due to collagen fiber (type I collagen) rearrangement and reorientation with aging that have not been researched until now. FTIR microspectroscopy appears as an interesting method to study protein structure under normal and pathological conditions. Associated with a polarizer, this vibrational technique permits us to probe collagen orientation within skin tissue sections, by computing the ratio of integrated intensities of amide I and amide II bands. In this study, we used the polarized-FTIR imaging to evaluate molecular modifications of dermal collagen during chronological aging. The data processing of polarized infrared data revealed that type I collagen fibers become parallel to the skin surface in aged skin dermis. Our approach could find innovative applications in dermatology as well as in cosmetics.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据