期刊
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
卷 12, 期 2-3, 页码 143-152出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10911-007-9046-4
关键词
motility; chemotaxis; invasion; cytoskeleton; metastasis
资金
- NCI NIH HHS [CA100324] Funding Source: Medline
Cell motility and chemotaxis can make important contributions to the metastatic cascade. Cell migration pathways in general play significant roles in a variety of physiological processes that can be hijacked by cancer cells. Both growth factors and chemokines provide important chemotactic signals in development and metastasis. Receptor activation, following binding of a growth factor or a chemokine, leads to dynamic morphological changes in the actin cytoskeleton network via a variety of distinct and interconnected pathways, resulting in translocation of the cell up a chemoattractant gradient. Such gradients may be produced by stromal cells in the local microenvironment, including macrophages and fibroblasts. A better understanding of the mechanisms of cell motility and cytoskeletal regulation may provide novel therapeutic strategies that would block metastatic progression, reducing dissemination of tumor cells and increasing patient survival.
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