期刊
ANALYST
卷 139, 期 21, 页码 5400-5408出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4an01225a
关键词
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资金
- Wellcome Trust [WT091285MA]
- Leverhulme Trust [F/00094/AW, ECF/2013-603]
- EPSRC [EP/K027263/1]
- Advantage West Midlands (AWM)
- European Regional Development Fund (ERDF)
- Birmingham Science City: Innovative Uses for Advanced Materials in the Modern World (West Midlands Centre for Advanced Materials Project) [2]
- Engineering and Physical Sciences Research Council [1510132, EP/K027263/1] Funding Source: researchfish
Herein, electrically switchable mixed self-assembled monolayers based on oligopeptides have been developed and investigated for their suitability in achieving control over biomolecular interactions in the presence of complex biological conditions. Our model system, a biotinylated oligopeptide tethered to gold within a background of tri(ethylene glycol) undecanethiol, is ubiquitous in both switching specific protein interactions in highly fouling media while still offering the non-specific protein-resistance to the surface. Furthermore, the work demonstrated that the performance of the switching on the electro-switchable oligopeptide is sensitive to the characteristics of the media, and in particular, its protein concentration and buffer composition, and thus such aspects should be considered and addressed to assure maximum switching performance. This study lays the foundation for developing more realistic dynamic extracellular matrix models and is certainly applicable in a wide variety of biological and medical applications.
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