期刊
DIAGNOSTIC MOLECULAR PATHOLOGY
卷 16, 期 3, 页码 158-168出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PDM.0b013e31804f54a9
关键词
posttransplant lymphoproliferative disorder; Epstein-Barr virus; gene expression profiling
资金
- NCATS NIH HHS [UL1 TR000005] Funding Source: Medline
- NCI NIH HHS [P01 CA47445] Funding Source: Medline
Although most posttransplant lymphoproliferative disorders (PTLD) are related to Epstein-Barr virus (EBV) infection, approximately 20% lack detectable EBV (EBV-). It is uncertain whether the latter cases are truly distinct from EBV+ PTLD or possibly relate to another infectious agent. This study used gene expression profiling to further investigate the relationship between EBV+ and EBV- monomorphic B-cell PTLD, and to search for clues to their pathogenesis. Affymetrix HU133A GeneChips were used to compare 4 EBV+ and 4 EBV - cases of monomorphic B-cell PTLD. Hierarchical clustering successfully distinguished the EBV+ and EBV - groups. Relative to EBV - PTLD, 54 transcripts were over-expressed in EBV + PTLD. The transcripts identified included IRF7 (a known regulator of EBV LMP1 expression), EBI2 (EBV-induced gene 2), and 3 that are interferon induced (MX1, IFITM1, and IFITM3). In addition, the EBV+ group contained 232 transcripts decreased relative to the EBV- group, including changes concordant with those previously reported after EBV infection of cultured B-cell lines. In summary, in a small group of monomorphic B-cell PTLD, EBV + cases demonstrated a subset of gene expression changes associated with EBV infection of B cells. By contrast, EBV - PTLD lacked viral-associated changes suggesting that they are biologically distinct.
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