期刊
JOURNAL OF IMMUNOLOGY
卷 179, 期 5, 页码 3222-3230出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.179.5.3222
关键词
-
类别
资金
- NIAID NIH HHS [AI 49388, T32 AI 52070] Funding Source: Medline
Efficacious adjuvants are important components of new vaccines. The neisserial outer membrane protein, PorB, is a TLR2 ligand with unique adjuvant activity. We demonstrate that PorB promotes Th2-skewed cellular immune response to the model Ag, OVA, in mice, including Ag-specific recall eosinophil recruitment to the peritoneum. PorB induces chemokine secretion by myeloid cells using both TLR2-dependent and -independent mechanisms, suggesting that anatomical distribution of LR2(+) cells may not be a limiting factor for potential vaccine strategies. The results from this study suggest that PorB, and other TLR2 ligands, may be ideal for use against pathogens where eosinophilia may be protective, such as parasitic helminths.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据