期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 55, 期 9, 页码 1376-1378出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.55.1376
关键词
aceriphyllum rossii; Saxifragaceae; triterpene; cytotoxicity
Bioassay-guided fractionation of a MeOH extract of the whole plant of Aceriphyllum rossii (Saxifragaceae) led to the isolation of two new triterpenes, 3 alpha,23-isopropylidenedioxyolean-12-en-27-oic acid (1) and 23-hydroxy-3-oxoolean-12-en-27-oic acid (2), together with six known triterpenes, 3-oxoolean-12-en-27-oic acid (3), 3 alpha-hydroxyolean-12-en-27-oic acid (4), beta-peltoboylkinolic acid (5), aceriphyllic acid A (6), olleanolic acid (7), and gypsogenic acid (8). The structures of these compounds were elucidated on the basis of physicochemical and spectroscopic analyses. These compounds were evaluated for in vitro cytotoxicity against the K562 and HL-60 cell lines. Olean-12-en-27-oic acid derivatives (1-6) exhibited considerable cytotoxicity against K562 and HL-60 cell lines with IC50 values ranging from 12.2 to 28.7 mu m and from 12.1 to 25.8 mu m, respectively.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据