期刊
BRITISH JOURNAL OF PSYCHIATRY
卷 191, 期 -, 页码 212-217出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1192/bjp.bp.107.036756
关键词
-
类别
Background Evidence from cross-sectional studies suggests a link between cerebral age-related white matter changes and depressive symptoms in older people, although the temporal association remains unclear. Aims To investigate age-related white matter changes on magnetic resonance imaging (MRI) as an independent predictor of depressive symptoms at 1 year after controlling for known confounders. Method In a pan-European multicentre study of 639 older adults without significant disability, MRI white matter changes and demographic and clinical variables, including cognitive scores, quality of life, disability and depressive symptoms, were assessed at baseline. Clinical assessments were repeated at 1 year. Results Using logistic regression analysis, severity of white matter changes was shown to independently and significantly predict depressive symptoms at I year after controlling for baseline depressive symptoms, quality of life and worsening disability (P < 0.0 1). Conclusions White matter changes pre-date and are associated with the development of depressive symptoms. This has implications for treatment and prevention of depression in later life.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据