期刊
ANALYST
卷 138, 期 4, 页码 1020-1025出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2an36116g
关键词
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资金
- National Institute for Biomedical Imaging and Bioengineering [5K25EB006011]
- Ocean Optics Blue Ocean Grants program
- Maryland NanoCenter
- NSF as a MRSEC Shared Experimental Facility
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [K25EB006011] Funding Source: NIH RePORTER
We demonstrate a paper-based surface swab and lateral-flow dipstick that includes an inkjet-printed surface-enhanced Raman spectroscopy (SERS) substrate for analyte detection. Due to capillary-action wicking of cellulose, the paper dipstick enables extremely simple and pump-free loading of liquid samples into the detection device, and in addition provides inherent analyte concentration within the detection volume. Furthermore, the flexible nature of the paper-based SERS device also enables it to act as a swab to collect analyte molecules directly from a large-area surface; the collected analyte molecules can then be focused into a small-volume SERS-active region by lateral-flow concentration. These capabilities are unseen in today's SERS substrates and microfluidic SERS devices. Using these novel lateral-flow paper SERS devices, we achieved detection limits as low as 95 fg of Rhodamine 6G (R6G), 413 pg of the organophosphate malathion, 9 ng of heroin, and 15 ng of cocaine. Moreover, the measurements show that the technique is quantitative and is repeatable across multiple swabs and dipsticks. The results reported here may lead to ultra-low-cost portable applications in trace chemical detection.
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