Tachykinin 1 (TAC1) gene SNPs and haplotypes with autism: A case-control study

Autism (MIM 209850) is a severe neurodevelopmental disorder characterized by disturbances in social interaction and communication, by repetitive body movements and restricted interests, and by atypical language development. Several twin and family studies have shown strong evidence for genetic factors in the etiology of autism. Glutamate is a major excitatory neurotransmitter in the human brain. Glutamate systems are involved in the pathophysiology of autism. There are many similarities between the symptoms evoked by glutamate antagonist treatment and symptoms of autism found in several human and animal studies. To elucidate the genetic background of autism, we analyzed the relationship between three single nucleotide polymorphisms (SNPs) of the Tachykinin 1 gene (TACI) and autism, because TACI is located in the candidate region for autism and produces substance P and neurokinins. These products modulate glutamatergic excitatory synaptic transmission and are also involved in inflammation. Many different inflammation-related mechanisms could be involved in the autistic brain. Therefore, TACI may have some functions associated with he presumable pathophysiology of autism. We compared the allele and haplotype frequencies between autistic patients (n = 170) and normal controls (n = 214) in the Japanese population, but no significant difference was observed. Thus, the TACI locus is not likely to play a major role in the development of autism. (c) 2007 Elsevier B.V. All rights reserved.